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pentobarbital will decrease the level or result of abemaciclib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of abemaciclib with powerful CYP3A4 inducers lowers plasma focus of abemaciclib and its metabolites.Pentobarbital may cause drowsiness and impair mental and Actual physical skills. Pr